Best Methylfolate Supplements (Updated January 2026)

Methylfolate Supplements are a smart choice for daily health and vitality. BuyersReport's experts have broken down the features, & benefits of the top-rated, most effective options so you can make an informed choice – our comprehensive review can help you find the best methylfolate supplement for your health needs.

Advertising Disclosure
1
Best Overall
Methylfolate for Brain Mood & Energy Support Triquetra

Methylfolate for Brain Mood & Energy Support

10.0 (871 reviews)
  • Supports mood, mental clarity & cognitive function naturally
  • Formulated to support overall cellular health and metabolic function
  • Promotes healthy homocysteine levels & nitric oxide production
  • Provides 7.5mg of active L-methylfolate with vitamin B9 +B12
  • Vegan, non-GMO, gluten, solvent & binder free, third-party tested
CHECK PRICE Amazon

Picked by 242 people today

2
Methyl + for Homocysteine, Brain & Heart Support LifeDNA

Methyl + for Homocysteine, Brain & Heart Support

9.9 (854 reviews)
  • Supports healthy homocysteine levels for better heart function & daily wellness
  • Helps boost methylation for improved focus, mood balance & steady energy
  • Active 5-MTHF with TMG offers bioavailable support for healthy cell function
  • Designed for simple daily use to maintain consistent methylation support
  • Non-GMO, clean-label formula, third-party tested & free from artificial additives
CHECK PRICE Amazon

Picked by 281 people today

Shop All Methylfolate Supplements
3
Methylfolate Supplement for Mood & Energy Nutricost

Methylfolate Supplement for Mood & Energy

9.7 (833 reviews)
  • Supports brain health, mood & metabolic function naturally
  • Helps maintain normal homocysteine levels for cardiovascular health
  • Formulated with high-quality ingredients for effective & reliable results
  • Provides 1000mcg of active methylfolate per serving, 120 capsules
  • Vegetarian, non-GMO, gluten free & third-party tested
CHECK PRICE Amazon

Picked by 133 people today

4
Methylfolate Supplement for Methylation Designs for Health

Methylfolate Supplement for Methylation

9.5 (1,200 reviews)
  • Helps maintain energy, cardiovascular health & cellular function
  • Designed to support mood, brain function & overall wellness naturally
  • Bloodstream-ready methylated folate ensures fast & effective absorption
  • Provides 1mg of Quatrefolic L-methylfolate, 120 capsules
  • Non-GMO, gluten free, vegan friendly & third-party tested
CHECK PRICE Amazon

Picked by 244 people today

5
High Potency Dual Action Methylfolate NatureBell

High Potency Dual Action Methylfolate

9.4 (1,267 reviews)
  • Enhances energy & cognitive support, promoting overall health & well-being
  • Maintains healthy neurological function for optimal mental performance
  • High-potency, dual action formula, trusted quality, 4-month supply
  • Provides 15mg of active L-methylfolate with 1,000mcg methyl B12
  • Non-GMO, gluten free, third-party tested, made in the USA
CHECK PRICE Amazon

Picked by 220 people today

6
Methylfolate for Energy Mood & Cellular Health Double Wood

Methylfolate for Energy Mood & Cellular Health

9.3 (914 reviews)
  • Helps naturally boost your energy, mental focus & general mood
  • Supports your heart, brain & overall health & wellness
  • Highly active folate that works better than regular folic acid
  • Delivers 1,000mcg of bioactive methylfolate for optimal absorption
  • Non-GMO, vegan friendly & third-party tested for purity & quality
50% Off CHECK PRICE Amazon

Picked by 214 people today

Shop All Methylfolate Supplements

Top Rated Methylfolate Supplement

1
Best Overall
Methylfolate for Brain Mood & Energy Support Triquetra

Methylfolate for Brain Mood & Energy Support

10.0 (871 reviews)
  • Supports mood, mental clarity & cognitive function naturally
  • Formulated to support overall cellular health and metabolic function
  • Promotes healthy homocysteine levels & nitric oxide production
  • Provides 7.5mg of active L-methylfolate with vitamin B9 +B12
  • Vegan, non-GMO, gluten, solvent & binder free, third-party tested
CHECK PRICE Amazon

Picked by 242 people today